Albendazole

Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.

Albendazole
Clinical data
Trade namesAlbenza, Eskazole, Valbazen, Zentel, others
AHFS/Drugs.comMonograph
MedlinePlusa610019
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only (for humans; veterinary suspension and paste are both OTC)
Pharmacokinetic data
Bioavailability<5%
Protein binding70%
MetabolismLiver
Elimination half-life8-12 hours
ExcretionBile duct (humans)
Kidney (ruminants)
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
ECHA InfoCard100.053.995
Chemical and physical data
FormulaC12H15N3O2S
Molar mass265.33 g·mol−1
3D model (JSmol)
Melting point208 to 210 °C (406 to 410 °F)
SMILES
  • CCCSc2ccc1nc(NC(=O)OC)[nH]c1c2
  • InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) Y
  • Key:HXHWSAZORRCQMX-UHFFFAOYSA-N Y
  (verify)

Common side effects include nausea, abdominal pain, and headache. Rare but potentially serious side effects include bone marrow suppression which usually improves on discontinuing the medication. Liver inflammation has been reported and those with prior liver problems are at greater risk. It is pregnancy category D in Australia, meaning it may cause harm if taken by pregnant women.

Albendazole was developed in 1975. It is on the World Health Organization's List of Essential Medicines.

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