Biperiden

Biperiden, sold under the brand name Akineton among others, is a medication used to treat Parkinson disease, certain drug-induced movement disorders and Tourette Syndrome. It is not recommended for tardive dyskinesias. It is taken by mouth, injection into a vein, or muscle.

Biperiden
Clinical data
Trade namesAkineton
AHFS/Drugs.comMonograph
MedlinePlusa699058
License data
Pregnancy
category
  • AU: B2
Routes of
administration		By mouth, intramuscular injection (IM), intravenous therapy (IV)
ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)
  • US: ℞-only
Pharmacokinetic data
Bioavailability33 ± 5% (by mouth)
Protein binding60%
MetabolismLiver hydroxylation
Elimination half-life18 to 24 hours
ExcretionKidney
Identifiers
  • (1RS,2SR,4RS)-1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin- 1-yl)propan-1-ol
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.007.441
Chemical and physical data
FormulaC21H29NO
Molar mass311.469 g·mol−1
3D model (JSmol)
SMILES
  • OC(c1ccccc1)(CCN2CCCCC2)C4C3\C=C/C(C3)C4
  • InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2 Y
  • Key:YSXKPIUOCJLQIE-UHFFFAOYSA-N Y
  (verify)

Common side effects include blurred vision, dry mouth, sleepiness, constipation, and confusion. It should not be used in people with a bowel obstruction or glaucoma. It is unclear if use in pregnancy or breastfeeding is safe. Biperiden is in the anticholinergic family of medication.

Biperiden was approved for medical use in the United States in 1959. It is on the World Health Organization's List of Essential Medicines. Biperiden is no longer marketed in the United States.

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