Agouti-related peptide

AGRP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HYK, 1MR0
Identifiers
Aliases	AGRP, agouti related neuropeptide, AGRT, ART, ASIP2, AgRP
External IDs	OMIM: 602311 MGI: 892013 HomoloGene: 7184 GeneCards: AGRP
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,483,547 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,364,025 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; right adrenal gland; ; corpus epididymis; ; right lung; ; caput epididymis; ; upper lobe of left lung; ; monocyte; ; hypothalamus; ; spleen; ; nucleus accumbens;
	Top expressed in
	median eminence; ; arcuate nucleus; ; morula; ; spermatocyte; ; entorhinal cortex; ; ventromedial nucleus; ; fossa; ; mammillary body; ; carotid body; ; adrenal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuropeptide hormone activity; signaling receptor binding;
Cellular component	Golgi lumen; extracellular region; neuronal cell body; Golgi apparatus; extracellular space;
Biological process	response to insulin; adult feeding behavior; neuropeptide signaling pathway; regulation of feeding behavior; positive regulation of feeding behavior; circadian rhythm; feeding behavior; eating behavior; maternal process involved in female pregnancy; hormone-mediated signaling pathway; long-day photoperiodism; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	181
	11604
	ENSG00000159723
	ENSMUSG00000005705
	O00253
	P56473
	NM_001138
	NM_001271806; NM_007427
	NP_001129
	NP_001258735; NP_031453
	Wikidata
View/Edit Human	View/Edit Mouse

Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is synthesized in neuropeptide Y (NPY)-containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalamus. AgRP is co-expressed with NPY and acts to increase appetite and decrease metabolism and energy expenditure. It is one of the most potent and long-lasting of appetite stimulators. In humans, the agouti-related peptide is encoded by the AGRP gene.

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