Adrenodoxin reductase

FDXR
Identifiers
Aliases	FDXR, ADXR, Adrenodoxin reductase, ferredoxin reductase, ANOA, ADR
External IDs	OMIM: 103270 MGI: 104724 HomoloGene: 3033 GeneCards: FDXR
Gene location (Human)
Chr.	Chromosome 17 (human)
End	74,873,031 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,167,876 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; spleen; ; skin of abdomen; ; stromal cell of endometrium; ; body of pancreas; ; right lobe of liver; ; epithelium of esophagus; ; body of stomach; ; vagina; ; ascending aorta;
	Top expressed in
	adrenal gland; ; ectoderm; ; saccule; ; otic placode; ; cumulus cell; ; superior frontal gyrus; ; spermatocyte; ; left lobe of liver; ; cerebellar cortex; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; ferredoxin-NADP+ reductase activity; NADPH-adrenodoxin reductase activity;
Cellular component	mitochondrion; mitochondrial inner membrane; mitochondrial matrix; membrane;
Biological process	C21-steroid hormone biosynthetic process; sterol metabolic process; cholesterol metabolic process; generation of precursor metabolites and energy; steroid biosynthetic process; lipid metabolism; steroid metabolic process; ubiquinone biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2232
	14149
	ENSG00000161513
	ENSMUSG00000018861
	P22570
	Q61578
NM_001258012; NM_001258013; NM_001258014; NM_001258015; NM_001258016;
	NM_004110; NM_024417
	NM_007997
NP_001244941; NP_001244942; NP_001244943; NP_001244944; NP_001244945;
	NP_004101; NP_077728
	NP_032023
	Wikidata
View/Edit Human	View/Edit Mouse

Adrenodoxin reductase (Enzyme Nomenclature name: adrenodoxin-NADP+ reductase, EC 1.18.1.6), was first isolated from bovine adrenal cortex where it functions as the first enzyme in the mitochondrial P450 systems that catalyze essential steps in steroid hormone biosynthesis. Examination of complete genome sequences revealed that adrenodoxin reductase gene is present in most metazoans and prokaryotes.

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