Adie syndrome

Adie's syndrome
Adie's syndrome
Other names	Holmes–Adie syndrome, Adie's tonic pupil, Holmes–Adie pupil
	Bilateral mydriasis given the observational diagnosis Adie's pupils by an ophthalmologist
Pronunciation	/ˈeɪdi/ ;
Specialty	Ophthalmology

Adie syndrome, also known as Holmes–Adie syndrome, is a neurological disorder characterized by a tonically dilated pupil that reacts slowly to light but shows a more definite response to accommodation (i.e., light-near dissociation). It is frequently seen in females with absent knee or ankle jerks and impaired sweating.

The syndrome is caused by damage to the postganglionic fibers of the parasympathetic innervation of the eye, usually by a viral or bacterial infection that causes inflammation, and affects the pupil of the eye and the autonomic nervous system. It is named after the British neurologists William John Adie and Gordon Morgan Holmes, who independently described the same disease in 1931.

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