Adenylosuccinate synthase
In molecular biology, adenylosuccinate synthase (or adenylosuccinate synthetase) (EC 6.3.4.4) is an enzyme that plays an important role in purine biosynthesis, by catalysing the guanosine triphosphate (GTP)-dependent conversion of inosine monophosphate (IMP) and aspartic acid to guanosine diphosphate (GDP), phosphate and N(6)-(1,2-dicarboxyethyl)-AMP. Adenylosuccinate synthetase has been characterised from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present: one involved in purine biosynthesis and the other in the purine nucleotide cycle.
| Adenylosuccinate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Adenylosuccinate synthetase dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 6.3.4.4 | ||||||||
| CAS no. | 9023-57-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Adenylsucc_synt | |||||||||
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structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana | |||||||||
| Identifiers | |||||||||
| Symbol | Adenylsucc_synt | ||||||||
| Pfam | PF00709 | ||||||||
| Pfam clan | CL0023 | ||||||||
| InterPro | IPR001114 | ||||||||
| PROSITE | PDOC00444 | ||||||||
| SCOP2 | 1ade / SCOPe / SUPFAM | ||||||||
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