Abemaciclib

Abemaciclib, sold under the brand name Verzenio among others, is a medication for the treatment of advanced or metastatic breast cancers. It was developed by Eli Lilly and it acts as a CDK inhibitor selective for CDK4 and CDK6.

Abemaciclib
Clinical data
Pronunciation/əˌbɛməˈsaɪklɪb/
ə-BEM-ə-SY-klib
Trade namesVerzenio, Verzenios, Ramiven, others
Other namesLY2835219
AHFS/Drugs.comMonograph
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only / Schedule D
  • US: ℞-only
  • EU: Rx-only
Pharmacokinetic data
Bioavailability45%
Protein binding96.3%
Elimination half-life18.3 hrs
Excretion81% via feces, 3% via urine
Identifiers
  • N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.233.787
Chemical and physical data
FormulaC27H32F2N8
Molar mass506.606 g·mol−1
3D model (JSmol)
SMILES
  • CCN1CCN(CC1)Cc2ccc(nc2)Nc3ncc(c(n3)c4cc5c(c(c4)F)nc(n5C(C)C)C)F
  • InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)
  • Key:UZWDCWONPYILKI-UHFFFAOYSA-N

It was designated as a breakthrough therapy for breast cancer by the US Food and Drug Administration (FDA) in October 2015.

In September 2017, it was approved for use in the United States by the FDA for the treatment of certain breast cancers.

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