AP2S1

AP2S1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JKR, 2JKT, 2VGL, 2XA7, 4UQI, 4NEE
Identifiers
Aliases	AP2S1, AP17, CLAPS2, FBH3, FBHOk, HHC3, adaptor related protein complex 2 sigma 1 subunit, adaptor related protein complex 2 subunit sigma 1
External IDs	OMIM: 602242 MGI: 2141861 HomoloGene: 3001 GeneCards: AP2S1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	46,850,846 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	16,483,219 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right adrenal gland; ; human penis; ; left adrenal gland; ; prefrontal cortex; ; cingulate gyrus; ; amygdala; ; vulva; ; dorsolateral prefrontal cortex; ; skin of abdomen;
	Top expressed in
	superior frontal gyrus; ; facial motor nucleus; ; neural tube; ; yolk sac; ; lip; ; thymus; ; anterior horn of spinal cord; ; cerebellar cortex; ; amygdala; ; maxillary prominence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transporter activity; clathrin adaptor activity; protein binding;
Cellular component	endocytic vesicle membrane; cytosol; clathrin-coated endocytic vesicle membrane; membrane; plasma membrane; endolysosome membrane; membrane coat; clathrin-coated pit; AP-2 adaptor complex; clathrin-coated endocytic vesicle; intracellular membrane-bounded organelle;
Biological process	regulation of endocytosis; endocytosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; ephrin receptor signaling pathway; mitigation of host defenses by virus; clathrin-dependent endocytosis; clathrin coat assembly; protein transport; intracellular protein transport; vesicle-mediated transport; microtubule-based movement; Wnt signaling pathway, planar cell polarity pathway; membrane organization; low-density lipoprotein particle receptor catabolic process; low-density lipoprotein particle clearance; transport;
	Sources:Amigo / QuickGO
Orthologs
	1175
	232910
	ENSG00000042753
	ENSMUSG00000008036
	P53680
	P62743
	NM_001301076; NM_001301078; NM_001301081; NM_004069; NM_021575
	NM_198613
	NP_001288005; NP_001288007; NP_001288010; NP_004060; NP_067586
	NP_941015
	Wikidata
View/Edit Human	View/Edit Mouse

AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene.

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.

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