Adaptor-related protein complex 2, alpha 1

AP2A1
Identifiers
Aliases	AP2A1, ADTAA, AP2-ALPHA, CLAPA1, Adaptor-related protein complex 2, alpha 1, adaptor related protein complex 2 alpha 1 subunit, adaptor related protein complex 2 subunit alpha 1
External IDs	OMIM: 601026 MGI: 101921 HomoloGene: 68997 GeneCards: AP2A1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,807,114 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,578,920 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; left adrenal gland; ; Brodmann area 9; ; stromal cell of endometrium; ; cingulate gyrus; ; prefrontal cortex; ; gastrocnemius muscle; ; left uterine tube; ; gastric mucosa; ; hypothalamus;
	Top expressed in
	superior frontal gyrus; ; spermatid; ; spermatocyte; ; lip; ; cerebellar cortex; ; dorsomedial hypothalamic nucleus; ; piriform cortex; ; yolk sac; ; neural tube; ; entorhinal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein C-terminus binding; clathrin adaptor activity; protein-containing complex binding; protein binding; protein kinase binding; low-density lipoprotein particle receptor binding;
Cellular component	endocytic vesicle membrane; cytosol; filopodium tip; membrane coat; apical plasma membrane; endolysosome membrane; clathrin adaptor complex; basolateral plasma membrane; clathrin-coated pit; clathrin coat of trans-Golgi network vesicle; clathrin-coated endocytic vesicle membrane; AP-2 adaptor complex; membrane; plasma membrane; clathrin-coated vesicle; protein-containing complex; clathrin-coated endocytic vesicle;
Biological process	ephrin receptor signaling pathway; mitigation of host defenses by virus; clathrin-dependent endocytosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; Golgi to endosome transport; transport; protein transport; vesicle-mediated transport; intracellular protein transport; endocytosis; microtubule-based movement; Wnt signaling pathway, planar cell polarity pathway; negative regulation of hyaluronan biosynthetic process; membrane organization; low-density lipoprotein particle receptor catabolic process; low-density lipoprotein particle clearance; positive regulation of neuron projection development; positive regulation of receptor-mediated endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	160
	11771
	ENSG00000196961
	ENSMUSG00000060279
	O95782
	P17426
	NM_014203; NM_130787
	NM_001077264; NM_007458
	NP_055018; NP_570603
	NP_001070732; NP_031484
	Wikidata
View/Edit Human	View/Edit Mouse

AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.

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