ANAPC2

ANAPC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 4YII, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC2, APC2, anaphase promoting complex subunit 2
External IDs	OMIM: 606946 MGI: 2139135 HomoloGene: 8359 GeneCards: ANAPC2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,188,560 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,175,927 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; tibial nerve; ; skin of abdomen; ; minor salivary glands; ; body of pancreas; ; body of stomach; ; left uterine tube; ; right lobe of thyroid gland; ; gastric mucosa; ; left lobe of thyroid gland;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; dermis; ; calvaria; ; utricle; ; neural tube; ; abdominal wall; ; ganglionic eminence; ; molar; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity; ubiquitin protein ligase binding; protein binding;
Cellular component	cytosol; nucleoplasm; anaphase-promoting complex; nucleus;
Biological process	cell differentiation; ubiquitin-dependent protein catabolic process; nervous system development; positive regulation of synaptic plasticity; protein K11-linked ubiquitination; cell division; positive regulation of synapse maturation; positive regulation of dendrite morphogenesis; protein ubiquitination; cell cycle; anaphase-promoting complex-dependent catabolic process; positive regulation of axon extension; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	29882
	99152
	ENSG00000176248
	ENSMUSG00000026965
	Q9UJX6
	Q8BZQ7
	NM_013366
	NM_175300
	NP_037498
	NP_780509
	Wikidata
View/Edit Human	View/Edit Mouse

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.

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