AMELX

AMELX
Identifiers
Aliases	AMELX, AI1E, AIH1, ALGN, AMG, AMGL, AMGX, amelogenin, X-linked, amelogenin X-linked, Amelogenin, X isoform
External IDs	OMIM: 300391 HomoloGene: 36056 GeneCards: AMELX
Gene location (Human)
Chr.	X chromosome (human)
End	11,300,761 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; optic nerve; ; deltoid muscle; ; lower lobe of lung; ; tibialis anterior muscle; ; temporal lobe; ; amygdala; ; kidney; ; male reproductive gland; ; prostate;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of tooth enamel; protein binding; hydroxyapatite binding; identical protein binding; growth factor activity;
Cellular component	extracellular region; cell surface; endoplasmic reticulum lumen; extracellular matrix; collagen-containing extracellular matrix; cytoplasm; Golgi apparatus; endocytic vesicle;
Biological process	positive regulation of collagen biosynthetic process; chondrocyte differentiation; biomineral tissue development; multicellular organism development; odontogenesis of dentin-containing tooth; cell adhesion; tooth mineralization; osteoblast differentiation; epithelial to mesenchymal transition; enamel mineralization; signal transduction; positive regulation of tooth mineralization; regulation of cell population proliferation; post-translational protein modification; regulation of signaling receptor activity; response to nutrient; response to calcium ion;
	Sources:Amigo / QuickGO
Orthologs
	265
	n/a
	ENSG00000125363
	n/a
	Q99217
	n/a
	NM_001142; NM_182680; NM_182681
	n/a
	NP_001133; NP_872621; NP_872622
	n/a
	Wikidata
View/Edit Human

Amelogenin, X isoform is a protein that in humans is encoded by the AMELX gene. AMELX is located on the X chromosome and encodes a set of isoforms of amelogenin by alternative splicing. Amelogenin is an extracellular matrix protein involved in the process of amelogenesis, the formation of enamel on teeth.

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