AKT1

AKT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H10, 1UNP, 1UNQ, 1UNR, 2UVM, 2UZR, 2UZS, 3CQU, 3CQW, 3MV5, 3MVH, 3O96, 3OCB, 3OW4, 3QKK, 3QKL, 3QKM, 4EJN, 4EKK, 4EKL, 4GV1, 5KCV
Identifiers
Aliases	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, AKT serine/threonine kinase 1
External IDs	OMIM: 164730 MGI: 87986 HomoloGene: 3785 GeneCards: AKT1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	104,795,751 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	112,641,318 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; right adrenal gland; ; right coronary artery; ; gallbladder; ; body of stomach; ; thoracic aorta; ; ascending aorta; ; popliteal artery; ; upper lobe of left lung;
	Top expressed in
	atrium; ; molar; ; submandibular gland; ; lip; ; external carotid artery; ; ganglionic eminence; ; dermis; ; internal carotid artery; ; epithelium of stomach; ; calvaria;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activating protein binding; kinase activity; nitric-oxide synthase regulator activity; ATP binding; protein kinase activity; protein phosphatase 2A binding; enzyme binding; phosphatidylinositol-3,4,5-trisphosphate binding; transferase activity; 14-3-3 protein binding; protein binding; protein serine/threonine/tyrosine kinase activity; protein kinase binding; protein kinase C binding; nucleotide binding; phosphatidylinositol-3,4-bisphosphate binding; identical protein binding; protein serine/threonine kinase activity; protein homodimerization activity; calmodulin binding;
Cellular component	cytoplasm; cytosol; membrane; cell-cell junction; mitochondrion; nucleus; ciliary basal body; microtubule cytoskeleton; plasma membrane; spindle; nucleoplasm; vesicle; postsynapse; protein-containing complex;
Biological process	germ cell development; positive regulation of glucose import; cellular response to nerve growth factor stimulus; positive regulation of protein phosphorylation; positive regulation of lipid biosynthetic process; regulation of neuron projection development; activation-induced cell death of T cells; response to heat; regulation of cell cycle checkpoint; response to organic substance; response to insulin-like growth factor stimulus; positive regulation of endodeoxyribonuclease activity; cellular response to DNA damage stimulus; regulation of protein localization; platelet activation; protein phosphorylation; cellular response to mechanical stimulus; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of fatty acid beta-oxidation; cell projection organization; cellular response to granulocyte macrophage colony-stimulating factor stimulus; positive regulation of blood vessel endothelial cell migration; glucose metabolic process; glycogen metabolic process; regulation of glycogen biosynthetic process; glycogen cell differentiation involved in embryonic placenta development; cell population proliferation; negative regulation of autophagy; cellular response to hypoxia; negative regulation of cell size; endocrine pancreas development; carbohydrate transport; negative regulation of proteolysis; insulin-like growth factor receptor signaling pathway; positive regulation of protein metabolic process; positive regulation of glycogen biosynthetic process; glucose homeostasis; labyrinthine layer blood vessel development; response to oxidative stress; negative regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; cellular response to prostaglandin E stimulus; positive regulation of cell growth; positive regulation of nitric-oxide synthase activity; maternal placenta development; regulation of myelination; protein ubiquitination; positive regulation of vasoconstriction; hyaluronan metabolic process; spinal cord development; cellular response to insulin stimulus; cellular response to decreased oxygen levels; protein autophosphorylation; inflammatory response; positive regulation of fat cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of neuron death; G protein-coupled receptor signaling pathway; cell differentiation; cellular response to peptide; negative regulation of protein kinase activity; phosphorylation; regulation of mRNA stability; negative regulation of release of cytochrome c from mitochondria; execution phase of apoptosis; cellular response to organic cyclic compound; positive regulation of DNA-binding transcription factor activity; positive regulation of glucose metabolic process; nervous system development; response to fluid shear stress; maintenance of protein location in mitochondrion; protein catabolic process; negative regulation of protein kinase activity by protein phosphorylation; osteoblast differentiation; response to UV-A; response to hormone; peptidyl-threonine phosphorylation; lipopolysaccharide-mediated signaling pathway; positive regulation of protein localization to nucleus; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; intracellular signal transduction; regulation of cell migration; peripheral nervous system myelin maintenance; nitric oxide biosynthetic process; positive regulation of endothelial cell proliferation; protein biosynthesis; positive regulation of nitric oxide biosynthetic process; cellular response to growth factor stimulus; T cell costimulation; regulation of nitric-oxide synthase activity; human ageing; mammary gland epithelial cell differentiation; cellular response to epidermal growth factor stimulus; multicellular organism development; negative regulation of JNK cascade; glycogen biosynthetic process; establishment of protein localization to mitochondrion; apoptotic mitochondrial changes; peptidyl-serine phosphorylation; positive regulation of sodium ion transport; response to growth hormone; positive regulation of apoptotic process; response to food; cellular response to vascular endothelial growth factor stimulus; striated muscle cell differentiation; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of fibroblast migration; regulation of translation; positive regulation of transcription by RNA polymerase II; signal transduction; negative regulation of endopeptidase activity; apoptotic process; positive regulation of epidermal growth factor receptor signaling pathway; interleukin-18-mediated signaling pathway; insulin receptor signaling pathway; positive regulation of smooth muscle cell proliferation; regulation of signal transduction by p53 class mediator; negative regulation of macroautophagy; TOR signaling; anoikis; positive regulation of organ growth; I-kappaB kinase/NF-kappaB signaling; phosphatidylinositol 3-kinase signaling; cellular response to reactive oxygen species; NIK/NF-kappaB signaling; positive regulation of transcription, DNA-templated; cellular response to cadmium ion; positive regulation of I-kappaB phosphorylation; epidermal growth factor receptor signaling pathway; positive regulation of cell population proliferation; positive regulation of mitochondrial membrane potential; regulation of apoptotic process; negative regulation of apoptotic process; positive regulation of protein localization to plasma membrane; carbohydrate metabolic process; activation of protein kinase B activity; protein kinase B signaling; negative regulation of protein kinase B signaling; excitatory postsynaptic potential; cellular response to tumor necrosis factor; cell migration involved in sprouting angiogenesis; positive regulation of gene expression; cytokine-mediated signaling pathway; negative regulation of protein ubiquitination; negative regulation of protein binding; positive regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of Notch signaling pathway; negative regulation of protein serine/threonine kinase activity; cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of G1/S transition of mitotic cell cycle; negative regulation of leukocyte cell-cell adhesion; positive regulation of protein localization to cell surface; negative regulation of lymphocyte migration; protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	207
	11651
	ENSG00000142208
	ENSMUSG00000001729
	P31749
	P31750
NM_001014431; NM_001014432; NM_005163; NM_001382430; NM_001382431;
	NM_001382432; NM_001382433
	NM_001165894; NM_009652; NM_001331107
NP_001014431; NP_001014432; NP_005154; NP_001369359; NP_001369360;
	NP_001369361; NP_001369362
	NP_001159366; NP_001318036; NP_033782
	Wikidata
View/Edit Human	View/Edit Mouse

RAC(Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains. It is commonly referred to as PKB, or by both names as "Akt/PKB".

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.