AKR1C2

AKR1C2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IHI, 1J96, 1XJB, 2HDJ, 2IPJ, 4JQ1, 4JQ2, 4JQ3, 4JQ4, 4JQA, 4JTQ, 4JTR, 4L1W, 4L1X, 4XO6, 4XO7
Identifiers
Aliases	AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD, DD-2, DD/BABP, aldo-keto reductase family 1, member C2, aldo-keto reductase family 1 member C2
External IDs	OMIM: 600450 MGI: 1924587 HomoloGene: 134114 GeneCards: AKR1C2
EC number	1.1.1.357
Gene location (Human)
Chr.	Chromosome 10 (human)
End	5,018,031 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	4,636,540 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; right lobe of liver; ; gallbladder; ; gastrocnemius muscle; ; ascending aorta; ; left coronary artery; ; minor salivary glands; ; tibial nerve; ; Achilles tendon; ; popliteal artery;
	Top expressed in
	kidney; ; proximal tubule; ; morula; ; secondary oocyte; ; blastocyst; ; spermatid; ; adrenal gland; ; liver; ; jejunum; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; alditol:NADP+ 1-oxidoreductase activity; phenanthrene 9,10-monooxygenase activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; bile acid binding; carboxylic acid binding; oxidoreductase activity; ketosteroid monooxygenase activity; alcohol dehydrogenase (NADP+) activity; steroid dehydrogenase activity;
Cellular component	cytoplasm; cytosol;
Biological process	prostaglandin metabolic process; G protein-coupled receptor signaling pathway; cellular response to jasmonic acid stimulus; steroid metabolic process; positive regulation of protein kinase B signaling; epithelial cell differentiation; daunorubicin metabolic process; doxorubicin metabolic process; lipid metabolism; progesterone metabolic process; digestion; cellular response to prostaglandin D stimulus; positive regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1646
	77337
	ENSG00000151632
	ENSMUSG00000021207
	P52895
	Q91WR5
	NM_001135241; NM_001354; NM_205845; NM_001321027; NM_001393392
	NM_029901
	NP_001128713; NP_001307956; NP_001345; NP_995317
	NP_084177
	Wikidata
View/Edit Human	View/Edit Mouse

Aldo-keto reductase family 1 member C2, also known as bile acid binding protein, 3α-hydroxysteroid dehydrogenase type 3 (3α-HSD3), and dihydrodiol dehydrogenase type 2, is an enzyme that in humans is encoded by the AKR1C2 gene.

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