AKR1C1

AKR1C1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MRQ, 3C3U, 3GUG, 3NTY, 4YVP
Identifiers
Aliases	AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB, aldo-keto reductase family 1, member C1, aldo-keto reductase family 1 member C1
External IDs	OMIM: 600449 MGI: 1924587 HomoloGene: 134114 GeneCards: AKR1C1
EC number	1.1.1.112
Gene location (Human)
Chr.	Chromosome 10 (human)
End	4,983,283 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	4,636,540 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; gastric mucosa; ; right lobe of liver; ; body of stomach; ; left coronary artery; ; ascending aorta; ; gallbladder; ; right lobe of thyroid gland; ; tibial nerve; ; minor salivary gland;
	Top expressed in
	kidney; ; proximal tubule; ; morula; ; secondary oocyte; ; blastocyst; ; spermatid; ; adrenal gland; ; liver; ; jejunum; ; submandibular gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; alditol:NADP+ 1-oxidoreductase activity; indanol dehydrogenase activity; aldo-keto reductase (NADP) activity; 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity; androsterone dehydrogenase (B-specific) activity; phenanthrene 9,10-monooxygenase activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; bile acid binding; protein binding; carboxylic acid binding; oxidoreductase activity; ketosteroid monooxygenase activity; alcohol dehydrogenase (NADP+) activity; steroid dehydrogenase activity;
Cellular component	cytoplasm; cytosol; extracellular exosome;
Biological process	cellular response to jasmonic acid stimulus; epithelial cell differentiation; daunorubicin metabolic process; doxorubicin metabolic process; progesterone metabolic process; bile acid metabolic process; digestion; retinal metabolic process; retinoid metabolic process; response to organophosphorus; bile acid and bile salt transport; intestinal cholesterol absorption; xenobiotic metabolic process; cholesterol homeostasis; protein homooligomerization; steroid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1645
	77337
	ENSG00000187134
	ENSMUSG00000021207
	Q04828
	Q91WR5
	NM_001353
	NM_029901
	NP_001344
	NP_084177
	Wikidata
View/Edit Human	View/Edit Mouse

Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene.

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