AK3L1

AK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AR7, 2BBW, 3NDP
Identifiers
Aliases	AK4, AK 4, AK3, AK3L1, AK3L2, adenylate kinase 4
External IDs	OMIM: 103030 MGI: 87979 HomoloGene: 100316 GeneCards: AK4
EC number	2.7.4.3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	65,232,145 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	101,324,192 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; right ventricle; ; pericardium; ; kidney; ; saphenous vein; ; lactiferous duct; ; internal globus pallidus; ; liver; ; nipple; ; entorhinal cortex;
	Top expressed in
	cumulus cell; ; secondary oocyte; ; kidney; ; proximal tubule; ; cerebellar vermis; ; blastocyst; ; subiculum; ; endocardial cushion; ; morula; ; primitive streak;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; nucleoside triphosphate adenylate kinase activity; GTP binding; phosphotransferase activity, phosphate group as acceptor; kinase activity; nucleobase-containing compound kinase activity; adenylate kinase activity; ATP binding; nucleoside monophosphate kinase activity; nucleoside diphosphate kinase activity; protein binding;
Cellular component	mitochondrial matrix; mitochondrion;
Biological process	nucleobase-containing small molecule interconversion; phosphorylation; nucleoside diphosphate phosphorylation; brain development; nucleoside triphosphate biosynthetic process; liver development; nucleobase-containing compound metabolic process; nucleoside monophosphate phosphorylation; AMP metabolic process; ATP metabolic process; GTP metabolic process; ADP biosynthetic process; regulation of oxidative phosphorylation; cellular response to hypoxia; regulation of ATP biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	205
	11639
	ENSG00000162433
	ENSMUSG00000028527
	P27144
	Q9WUR9
	NM_203464; NM_001005353; NM_013410; NM_001330616
	NM_001177602; NM_001177604; NM_001177605; NM_009647
	NP_001005353; NP_001317545; NP_037542; NP_982289
	NP_001171073; NP_001171075; NP_001171076; NP_033777
	Wikidata
View/Edit Human	View/Edit Mouse

Adenylate kinase isoenzyme 4, mitochondrial is an enzyme that in humans is encoded by the AK4 gene.

This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. Expression of AK4 may regulate global cellular ATP levels and modulate the AMPK signaling pathway.

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