Alpha-actinin-1

ACTN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EYI, 2EYN, 2N8Z, 2N8Y
Identifiers
Aliases	ACTN1, BDPLT15, actinin alpha 1
External IDs	OMIM: 102575 MGI: 2137706 HomoloGene: 55553 GeneCards: ACTN1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	68,979,440 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	80,307,145 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; ascending aorta; ; right coronary artery; ; popliteal artery; ; stromal cell of endometrium; ; smooth muscle tissue; ; myometrium; ; gastric mucosa; ; left coronary artery; ; seminal vesicula;
	Top expressed in
	stria vascularis; ; ascending aorta; ; external carotid artery; ; internal carotid artery; ; ciliary body; ; uterus; ; belly cord; ; cervix; ; calvaria; ; semi-lunar valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein homodimerization activity; transmembrane transporter binding; vinculin binding; metal ion binding; integrin binding; actin filament binding; protein binding; nuclear receptor coactivator activity; double-stranded RNA binding; actin binding; structural constituent of postsynapse;
Cellular component	cytoplasm; cytosol; cell projection; pseudopodium; membrane; cell-cell junction; focal adhesion; ruffle; plasma membrane; intracellular anatomical structure; stress fiber; extracellular region; cell junction; Z disc; brush border; actin filament; fascia adherens; extracellular exosome; cytoskeleton; platelet alpha granule lumen; sarcomere; extracellular space; glutamatergic synapse;
Biological process	regulation of apoptotic process; actin filament organization; actin filament network formation; platelet degranulation; platelet formation; actin filament bundle assembly; focal adhesion assembly; actin crosslink formation; platelet morphogenesis; platelet aggregation; platelet activation; regulation of nucleic acid-templated transcription; postsynapse organization; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	87
	109711
	ENSG00000072110
	ENSMUSG00000015143
	P12814
	Q7TPR4
	NM_001102; NM_001130004; NM_001130005
	NM_134156; NM_001346669; NM_001379075; NM_001379076
	NP_001093; NP_001123476; NP_001123477; NP_001093.1
	NP_001333598; NP_598917; NP_001366004; NP_001366005
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.

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