ACTH receptor

MC2R
Identifiers
Aliases	MC2R, ACTHR, melanocortin 2 receptor
External IDs	OMIM: 607397 MGI: 96928 HomoloGene: 444 GeneCards: MC2R
Gene location (Human)
Chr.	Chromosome 18 (human)
End	13,915,707 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	68,562,391 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; left adrenal gland; ; metanephros; ; pituitary gland; ; anterior pituitary; ; appendix; ; testicle; ; monocyte; ; ventricle; ; left ventricle;
	Top expressed in
	adrenal gland; ; white adipose tissue; ; adrenal cortex; ; brown adipose tissue; ; subcutaneous adipose tissue; ; ankle; ; striated muscle tissue; ; skin of abdomen; ; skeletal muscle tissue; ; sexually immature organism;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	melanocortin receptor activity; protein binding; G protein-coupled receptor activity; corticotropin receptor activity; signal transducer activity;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; signal transduction; placenta development; neuropeptide signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4158
	17200
	ENSG00000185231
	ENSMUSG00000045569
	Q01718
	Q64326
	NM_001291911; NM_000529
	NM_001271716; NM_001271717; NM_008560; NM_001301372
	NP_000520; NP_001278840
	NP_001258645; NP_001258646; NP_001288301; NP_032586
	Wikidata
View/Edit Human	View/Edit Mouse

The adrenocorticotropic hormone receptor or ACTH receptor also known as the melanocortin receptor 2 or MC₂ receptor is a type of melanocortin receptor (type 2) which is specific for ACTH. A G protein–coupled receptor located on the external cell plasma membrane, it is coupled to G_αs and upregulates levels of cAMP by activating adenylyl cyclase. The ACTH receptor plays a role in immune function and glucose metabolism.

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