7-Dehydrocholesterol reductase

DHCR7
Identifiers
Aliases	DHCR7, SLOS, 7-dehydrocholesterol reductase
External IDs	OMIM: 602858 MGI: 1298378 HomoloGene: 1042 GeneCards: DHCR7
EC number	1.3.1.21
Gene location (Human)
Chr.	Chromosome 11 (human)
End	71,452,868 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	143,402,147 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; oocyte; ; islet of Langerhans; ; secondary oocyte; ; skin of abdomen; ; corpus epididymis; ; ganglionic eminence; ; prefrontal cortex; ; hypothalamus; ; retinal pigment epithelium;
	Top expressed in
	adrenal gland; ; lip; ; cumulus cell; ; motor neuron; ; left lobe of liver; ; left colon; ; condyle; ; ectoderm; ; skin of back; ; otic placode;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; oxidoreductase activity; NADP binding; 7-dehydrocholesterol reductase activity; sterol delta7 reductase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; integral component of endoplasmic reticulum membrane; endoplasmic reticulum; nuclear outer membrane; cytosol;
Biological process	cell differentiation; steroid metabolic process; sterol biosynthetic process; multicellular organism growth; lung development; lipid metabolism; cholesterol metabolic process; post-embryonic development; blood vessel development; regulation of cell population proliferation; cholesterol biosynthetic process via lathosterol; cholesterol biosynthetic process via desmosterol; steroid biosynthetic process; cholesterol biosynthetic process; brassinosteroid biosynthetic process; regulation of cholesterol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1717
	13360
	ENSG00000172893
	ENSMUSG00000058454
	Q9UBM7
	O88455
	NM_001163817; NM_001360
NM_007856; NM_001382498; NM_001382499; NM_001382500; NM_001382501;
	NM_001382502; NM_001382503
	NP_001157289; NP_001351
NP_031882; NP_001369427; NP_001369428; NP_001369429; NP_001369430;
	NP_001369431; NP_001369432
	Wikidata
View/Edit Human	View/Edit Mouse

7-Dehydrocholesterol reductase, also known as DHCR7, is a protein that in humans is encoded by the DHCR7 gene.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.