3α-Hydroxysteroid dehydrogenase

AKR1C4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FVL
Identifiers
Aliases	AKR1C4, 3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA, aldo-keto reductase family 1, member C4, aldo-keto reductase family 1 member C4
External IDs	OMIM: 600451 MGI: 1933427 HomoloGene: 84695 GeneCards: AKR1C4
EC number	1.1.1.225
Gene location (Human)
Chr.	Chromosome 10 (human)
End	5,218,949 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	4,507,876 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gallbladder; ; islet of Langerhans; ; duodenum; ; jejunal mucosa; ; Achilles tendon; ; right uterine tube; ; blood; ; kidney; ; kidney;
	Top expressed in
	left lobe of liver; ; gallbladder; ; bronchus; ; urethra; ; lobar bronchus; ; abdominal aorta; ; proximal convoluted tubule; ; sexually immature organism; ; vein; ; semicircular canal;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	retinal dehydrogenase activity; aldo-keto reductase (NADP) activity; bile acid transmembrane transporter activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; chlordecone reductase activity; electron transfer activity; oxidoreductase activity; androsterone dehydrogenase activity; alditol:NADP+ 1-oxidoreductase activity; alcohol dehydrogenase (NADP+) activity; steroid dehydrogenase activity; ketosteroid monooxygenase activity;
Cellular component	cytoplasm; cytosol; extracellular exosome;
Biological process	cellular response to jasmonic acid stimulus; steroid metabolic process; daunorubicin metabolic process; doxorubicin metabolic process; androgen metabolic process; retinoid metabolic process; bile acid and bile salt transport; bile acid biosynthetic process; electron transport chain; prostaglandin metabolic process; progesterone metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1109
	83702
	ENSG00000198610
	ENSMUSG00000021210
	P17516
	P70694
	NM_001818
	NM_030611
	NP_001809
	NP_085114
	Wikidata
View/Edit Human	View/Edit Mouse

3α-Hydroxysteroid dehydrogenase type 1 (3α-HSD1) or aldo-keto reductase family 1 member C4 is an enzyme that in humans is encoded by the AKR1C4 gene. It is known to be necessary for the synthesis of the endogenous neurosteroids allopregnanolone, THDOC, and 3α-androstanediol. It is also known to catalyze the reversible conversion of 3α-androstanediol (5α-androstane-3α,17β-diol) to dihydrotestosterone (DHT, 5α-androstan-17β-ol-3-one) and vice versa.

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