2022 US Open – Men's singles

Carlos Alcaraz defeated Casper Ruud in the final, 6–4, 2–6, 7–6^(7–1), 6–3 to win the men's singles tennis title at the 2022 US Open. It was his first major title. He claimed the world No. 1 singles ranking with the win; Ruud, Rafael Nadal, Daniil Medvedev, and Stefanos Tsitsipas were also in contention for the top position. Alcaraz saved a match point en route to the title, in the quarterfinals against Jannik Sinner. Alcaraz became the youngest major champion since Nadal at the 2005 French Open, the youngest US Open champion since Pete Sampras in 1990, the first man born in the 2000s to win a major singles title, and the youngest man to be ranked world No. 1, surpassing Lleyton Hewitt's record. Alcaraz also became the third player to reach a major final having won three consecutive five-set matches, after Stefan Edberg at the 1992 US Open and Andre Agassi at the 2005 US Open. At 23 hours and 39 minutes of play duration across his seven matches, Alcaraz spent the longest time on court in major history until then, a record that was later broken by Daniil Medvedev at the 2024 Australian Open. Ruud became the first Norwegian to reach the final.

Daniil Medvedev was the defending champion, but lost in the fourth round to Nick Kyrgios. Medvedev became the first man outside the Big Four to be the top seed at a major since Andy Roddick at the 2004 Australian Open.

This marked the third consecutive US Open where a player claimed his first major title. The quarterfinal line-up guaranteed a first-time major champion, while the semifinal line-up marked the first time all four players made their US Open semifinal debut since the inaugural edition in 1881.

Frances Tiafoe became the first American man to reach the semifinals since Roddick in 2006, and the semifinals of any major since John Isner at the 2018 Wimbledon Championships. Tiafoe also became the first African American man to reach the semifinals since Arthur Ashe in 1972 and the first to reach any major semifinal since MaliVai Washington in 1996. Sinner became the youngest man to reach the quarterfinals at all four majors since Novak Djokovic in 2008.

Nadal was vying for a record-extending 23rd major singles title, but lost in the fourth round to Tiafoe. That marked the first US Open since 2000 and the first major since the 2017 Australian Open with neither of the top two seeded men reaching the quarterfinals. Three-time champion and nine-time finalist Djokovic withdrew prior to the tournament as he could not travel to the United States, due to not having complied with the federal government's vaccination policy for non-US citizens against COVID-19.

This was the first edition of US Open to feature a 10-point tie-break, when the score reaches six games all in the deciding set. Pedro Cachin defeated Aljaž Bedene in the first round in the first main-draw 10-point tie-break at the US Open.