2022 San Diego Open – Men's singles
Brandon Nakashima defeated Marcos Giron in the final, 6–4, 6–4 to win the singles tennis title at the 2022 San Diego Open. It was his first ATP Tour title, and he won it in his hometown of San Diego.
| Men's singles | |
|---|---|
| 2022 San Diego Open | |
| Champion | Brandon Nakashima |
| Runner-up | Marcos Giron |
| Score | 6–4, 6–4 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
Casper Ruud was the reigning champion, but competed at the Laver Cup instead.
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