2022 I.ČLTK Prague Open – Men's singles

The men's singles of the 2022 I.ČLTK Prague Open tournament took place on clay in Prague, Czech Republic.

Men's singles
2022 I.ČLTK Prague Open
Champion Pedro Cachin
Runner-up Lorenzo Giustino
Score6–3, 7–6(7–4)

Tallon Griekspoor was the defending champion but chose not to compete.

Pedro Cachin won the title after defeating Lorenzo Giustino 6–3, 7–6(7–4) in the final.

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