2022 Australian Open – Women's singles

Ashleigh Barty defeated Danielle Collins in the final, 6–3, 7–6^(7–2) to win the women's singles tennis title at the 2022 Australian Open. It was her third major singles title. Barty became the first home player to win an Australian Open singles title since Chris O'Neil in 1978. Barty did not drop a set during the tournament. The final also marked Barty's last professional appearance, as she announced her retirement from the sport two months later.

Naomi Osaka was the defending champion, but lost to Amanda Anisimova in the third round.

Barty retained the world No. 1 singles ranking after Aryna Sabalenka and Barbora Krejčíková lost in the fourth round and quarterfinals, respectively. Collins entered the top 10 in the rankings for the first time by reaching the final.

Alizé Cornet reached her first major singles quarterfinal on her 63rd main-draw appearance, surpassing Tamarine Tanasugarn's all-time record, who reached her first quarterfinal at the 2008 Wimbledon Championships on her 45th attempt. Kaia Kanepi became the first Estonian to reach the quarterfinals at all four majors. For the first time since 1997, neither Venus nor Serena Williams participated in the Australian Open.

This was the last singles major for former world No. 4 and 2011 US Open champion Samantha Stosur, who announced her retirement from the discipline. She lost to Anastasia Pavlyuchenkova in the second round.