2022 Australian Open – Men's singles

Rafael Nadal defeated Daniil Medvedev in the final, 2–6, 6–7^(5–7), 6–4, 6–4, 7–5 to win the men's singles tennis title at the 2022 Australian Open. It was his second Australian Open title and 21st major singles title overall, surpassing the all-time record he had jointly held with Roger Federer and Novak Djokovic. Nadal became the fourth man, after Roy Emerson, Rod Laver, and Djokovic, to achieve the double career Grand Slam, and the second in the Open Era. He also became the first man in the Open Era to win an Australian Open final after losing the first two sets. This marked the third consecutive year a man trailed by two sets in a major final yet rallied to win, following Djokovic's two-set comeback at the 2021 French Open and Dominic Thiem's at the 2020 US Open.

Djokovic was the three-time reigning champion, but did not compete after his visa was cancelled shortly before the tournament began due to an intervention from Australia's Immigration Minister Alex Hawke, citing risks to public health and good order in Australia. That meant Nadal was the only former champion (2009) to compete in the tournament, with both Federer and Stan Wawrinka sidelined by injury. Djokovic retained the world No. 1 singles ranking despite being unable to defend his points after Medvedev and Alexander Zverev lost in the final and fourth round, respectively.

Matteo Berrettini became the first man born in the 1990s to reach the quarterfinals at all four majors, and the first Italian man to reach the semifinals of the Australian Open.