2021 Serbia Open – Men's singles
Matteo Berrettini defeated Aslan Karatsev in the final, 6–1, 3–6, 7–6(7–0) to win the men's singles tennis title at the 2021 Serbia Open.
| Men's singles | |
|---|---|
| 2021 Serbia Open | |
| Champion | Matteo Berrettini |
| Runner-up | Aslan Karatsev |
| Score | 6–1, 3–6, 7–6(7–0) |
| Draw | 28 (4 Q/ 3 WC) |
| Seeds | 8 |
Andreas Seppi was the reigning champion from when the event was last held in 2012, but he decided not to participate this year.
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