2021 Prague Open – Singles
Simona Halep was the defending champion, but chose not to participate.
| Singles | |
|---|---|
| 2021 Prague Open | |
| Champion | Barbora Krejčíková |
| Runner-up | Tereza Martincová |
| Score | 6–2, 6–0 |
| Draw | 32 |
| Seeds | 8 |
Barbora Krejčíková won the title, defeating Tereza Martincová in the final, 6–2, 6–0.
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