2021 Internazionali Femminili di Palermo – Singles
Fiona Ferro was the defending champion, but she chose not to participate, as she was competing at the Summer Olympics.
| Singles | |
|---|---|
| 2021 Internazionali Femminili di Palermo | |
| Champion | Danielle Collins |
| Runner-up | Elena-Gabriela Ruse |
| Score | 6–4, 6–2 |
| Draw | 32 |
| Seeds | 8 |
Top seed Danielle Collins won her maiden WTA Tour singles title, defeating Elena-Gabriela Ruse in the final, 6–4, 6–2. Collins did not drop a set during the tournament.
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