2021 Hamburg European Open – Women's singles
Kim Clijsters was the defending champion, having won the previous edition in 2002, but chose not to participate.
| Women's singles | |
|---|---|
| 2021 Hamburg European Open | |
| Champion | Elena-Gabriela Ruse |
| Runner-up | Andrea Petkovic |
| Score | 7–6(8–6), 6–4 |
Elena-Gabriela Ruse won her maiden WTA Tour singles title as a qualifier, defeating Andrea Petkovic in the final, 7–6(8–6), 6–4.
This tournament marked Dayana Yastremska's return to professional tennis, after her suspension for testing positive for a prohibited substance was lifted by the ITF.
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