2021 Grand National

The 2021 Grand National (officially known as the Randox 2021 Grand National for sponsorship reasons) was the 173rd annual running of the Grand National horse race, held at Aintree Racecourse in Liverpool, England, on 10 April 2021. The event was once again sponsored by Randox Health, although the name on the race from this year onwards was shortened to simply "Randox". The total prize fund for the race was £750,000, down by £250,000 from the last meeting in 2019.

The race was won by Minella Times, trained by Henry de Bromhead and ridden by Rachael Blackmore, who became the first female jockey to win the Grand National. De Bromhead, who won the race as a trainer for the first time, also trained the second-place finisher Balko des Flos. The winner was owned by J. P. McManus, who had previously won the race as an owner in 2010 with Don't Push It. The Long Mile was euthanised after fracturing a hind leg. Jockey Bryony Frost was treated for injuries after falling from Yala Enki.

Having been cancelled the year before due to the COVID-19 pandemic, the 2021 race and entire festival meeting took place behind closed doors for the first time in its history, because of continuing restrictions. Despite speculations and calls from some leading figures in racing for the meeting to be pushed back in the calendar so that it could possibly take place when betting shops are open, it was confirmed the race would retain its original date.

The death of Prince Philip, Duke of Edinburgh was announced shortly before the second day of the meeting. The meeting continued as scheduled, with tributes including a two-minute silence before racing, jockeys wearing black armbands on their silks as a mark of respect and the Union Jack on the Queen Mother Stand being lowered to half-mast.