2021 Copa Colsanitas – Singles
Camila Osorio defeated Tamara Zidanšek in the final, 5–7, 6–3, 6–4 to win the singles tennis title at the 2021 Copa Colsanitas. It was the Colombian teenage wildcard's first WTA Tour singles title. Ranked No. 180, Osorio became the lowest-ranked WTA title holder since world No. 299 Margarita Gasparyan at the 2018 Tashkent Open. Zidanšek was also in contention for her first WTA title.
| Singles | |
|---|---|
| 2021 Copa Colsanitas | |
| Champion | Camila Osorio |
| Runner-up | Tamara Zidanšek |
| Score | 5–7, 6–3, 6–4 |
| Draw | 32 |
| Seeds | 8 |
Amanda Anisimova was the reigning champion from when the tournament was last held in 2019, but chose to compete in Charleston instead.
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