2021 Córdoba Open – Singles

Cristian Garín was the defending champion, but chose not to defend his title.

Singles
2021 Córdoba Open
Champion Juan Manuel Cerúndolo
Runner-up Albert Ramos Viñolas
Score6–0, 2–6, 6–2
Draw28 (4 Q / 3 WC )
Seeds8

Juan Manuel Cerúndolo won the title, defeating Albert Ramos Viñolas in the final 6–0, 2–6, 6–2. Cerúndolo, who started the week ranked 335th and went through qualifying, became the first player to win a tournament on his ATP Tour debut since Santiago Ventura in 2004.

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