2019 US Open – Women's singles

Bianca Andreescu defeated Serena Williams in the final, 6–3, 7–5 to win the women's singles tennis title at the 2019 US Open. It was her first major title, and she became the first Canadian, as well as the first player born in the 2000s, to win a major singles title. In addition, she was the youngest player since Svetlana Kuznetsova in 2004 to win a major singles title, and the first woman to win the US Open on her main draw debut. With the win, Andreescu entered the top 5 in rankings for the first time.

Naomi Osaka was the defending champion, but lost to Belinda Bencic in the fourth round.

It marked the first time in history that the tournament's draw included eight champions: Osaka, Sloane Stephens, Angelique Kerber, Serena Williams, Samantha Stosur, Maria Sharapova, Kuznetsova, and Venus Williams.

In reaching her 33rd and last career major final, Williams set a new record for the longest gap between a player's first and last major final appearances, her first being twenty years prior at the 1999 US Open. She also equaled the record for the most match wins at the US Open held by Chris Evert (101 wins). Williams was attempting to equal Margaret Court's all-time record of 24 major singles titles, and to win an Open Era record seventh US Open title.

Despite losing in the fourth round, Ashleigh Barty regained the world No. 1 ranking from Osaka. In addition to Barty and Osaka, Karolína Plíšková and Simona Halep were also in contention for the top ranking.