2017 US Open – Men's singles

Rafael Nadal defeated Kevin Anderson in the final, 6–3, 6–3, 6–4 to win the men's singles tennis title at the 2017 US Open. It was his third US Open title and 16th major title overall. It was also his first hard court title since January 2014.

Stan Wawrinka was the reigning champion, but did not participate due to a knee injury that ended his season prematurely. Wawrinka's withdrawal ended his streak of 50 consecutive major appearances, dating back to the 2005 French Open. Reigning finalist Novak Djokovic also withdrew due to an elbow injury that ended his season, ending his streak of 51 consecutive major appearances, dating back to the 2005 Australian Open. Accordingly, this was the first men's singles draw at the US Open since 1971 to include neither finalist from the previous year's tournament.

After the loss of Marin Čilić in the third round, a first-time major finalist was guaranteed from the bottom half of the draw. Anderson was the first South African man to reach the final since Cliff Drysdale in 1965, and at any major singles final since Kevin Curren at the 1984 Australian Open, as well as the lowest-ranked man to reach the US Open singles final since the ATP rankings began in 1973. Anderson was also the tallest major finalist in history, at 6 feet 8 inches.

Nadal, Roger Federer and Andy Murray were in contention for the world No. 1 singles ranking at the start of the tournament. Nadal retained the top ranking following Murray's withdrawal and Federer's loss in the quarterfinals.

Federer broke the men's singles record for total appearances at majors with his 71st participation. He was attempting to go undefeated at the majors for the season (having won the Australian Open and Wimbledon Championships and not played the French Open), but lost to Juan Martín del Potro in the quarterfinals. Andrey Rublev became the youngest man to reach the US Open quarterfinals since Andy Roddick in 2001, and Denis Shapovalov became the youngest man to reach the fourth round of the US Open since Michael Chang in 1989. Sam Querrey became the first American man to reach the quarterfinals of the US Open since John Isner and Andy Roddick in 2011. Diego Schwartzman became the shortest man (5 feet 7 inches) to reach a major singles quarterfinal since Jaime Yzaga (also 5 feet 7 inches) at the 1994 US Open.

This tournament marked the first US Open main draw appearance of future world No. 1 and 2021 US Open champion Daniil Medvedev; he lost in the first round to Shapovalov.