2016 US Open – Men's singles
Stan Wawrinka defeated the defending champion Novak Djokovic in the final, 6–7(1–7), 6–4, 7–5, 6–3 to win the men's singles tennis title at the 2016 US Open. It was his third major title; on all three occasions, he defeated the world No. 1 player in the final. Wawrinka saved a match point en route to the title, against Dan Evans in the third round. Djokovic became the third man in the Open Era (after Ivan Lendl and Andy Murray) to lose five finals at the same major.
| Men's singles | |
|---|---|
| 2016 US Open | |
| Champion | Stan Wawrinka |
| Runner-up | Novak Djokovic |
| Score | 6–7(1–7), 6–4, 7–5, 6–3 |
| Draw | 128 (16 Q / 8 WC ) |
| Seeds | 32 |
This was the first US Open since 1999 not to feature five-time champion Roger Federer. This was the first major that Tomáš Berdych, then the world No. 8, missed ever since his debut at the 2003 US Open, ending his streak of 52 consecutive Grand Slam appearances (sixth-highest of all-time).
No American player was seeded inside the top 16 for the first time since the introduction of the seeding system in 1930. Steve Johnson was the top-seeded American man at No. 19.