2016 Australian Open – Men's singles

Defending champion Novak Djokovic defeated Andy Murray in a rematch of the previous year's final, 6–1, 7–5, 7–6^(7–3) to win the men's singles tennis title at the 2016 Australian Open. It was his record-equaling sixth Australian Open men's singles title (tying Roy Emerson) and eleventh major title overall. This was the fourth Australian Open final between the pair. Murray became the second man in the Open Era to lose five finals at the same major (after Ivan Lendl at the US Open), and is the only one to have the distinction without having won the title.

Australian Lleyton Hewitt, a former finalist, two-time major champion and former world No. 1, played his last professional singles match at this event. He lost to David Ferrer in the second round.