2012 US Open – Mixed doubles
Melanie Oudin and Jack Sock were the defending champions, but were defeated by Sania Mirza and Colin Fleming in the second round.
| Mixed doubles | |
|---|---|
| 2012 US Open | |
| Champion | Ekaterina Makarova Bruno Soares |
| Runner-up | Květa Peschke Marcin Matkowski |
| Score | 6–7(8–10), 6–1, [12–10] |
Ekaterina Makarova and Bruno Soares won the title, defeating Květa Peschke and Marcin Matkowski in the final 6–7(8–10), 6–1, [12–10].
Kim Clijsters played her final professional match before her retirement later this year in this tournament, partnering Bob Bryan. The pair were defeated by Makarova and Soares in the second round. Clijsters would return to professional tennis in 2020.
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