2011 US Open – Men's singles

Novak Djokovic defeated the defending champion Rafael Nadal in a rematch of the previous year's final, 6–2, 6–4, 6–7^(3–7), 6–1 to win the men's singles tennis title at the 2011 US Open. It was his first US Open title and fourth major title overall. Djokovic saved match points en route to the title, saving two against Roger Federer in the semifinals. This was the second consecutive US Open where Djokovic saved two match points against Federer to reach the final, and the fifth consecutive US Open where Djokovic and Federer played each other. With the loss, Federer failed to win a major in a calendar year for the first time since 2002.

Andy Roddick and John Isner, who both lost in the quarterfinals, became the last American men to reach the quarterfinals of a major until Sam Querrey at the 2016 Wimbledon Championships, a span of 22 events.

This was the last major for former world No. 5 Fernando González, and the last US Open appearances for 2003 finalist and former world No. 1 Juan Carlos Ferrero, former world No. 3 David Nalbandian, and former world No. 3 Ivan Ljubičić.