2010 US Open – Women's singles

Defending champion Kim Clijsters defeated Vera Zvonareva in the final, 6–2, 6–1 to win the women's singles tennis title at the 2010 US Open. It was her third US Open title and third major title overall.

Women's singles
2010 US Open
Champion Kim Clijsters
Runner-up Vera Zvonareva
Score6–2, 6–1
Draw128
Seeds32

World No. 1 and three-time champion Serena Williams withdrew from the tournament due to a foot surgery sustained from an exhibition match. Caroline Wozniacki was in contention to gain the top ranking by winning the title, but lost to Zvonareva in the semifinals.

This was the final major appearance for former world No. 3 Elena Dementieva; she was defeated in the fourth round by Samantha Stosur.

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