2010 US Open – Mixed doubles
Carly Gullickson and Travis Parrott were the defending champions, but lost in the first round to Gisela Dulko and Pablo Cuevas.
| Mixed doubles | |
|---|---|
| 2010 US Open | |
| Champion | Liezel Huber Bob Bryan |
| Runner-up | Květa Peschke Aisam-ul-Haq Qureshi |
| Score | 6–4, 6–4 |
Liezel Huber and Bob Bryan won the title, defeating Květa Peschke and Aisam-ul-Haq Qureshi in the final 6–4, 6–4.
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