2006 US Open – Women's singles
Maria Sharapova defeated Justine Henin-Hardenne in the final, 6–4, 6–4 to win the women's singles tennis title at the 2006 US Open. It was her second major title. She lost just one set during the tournament (to Amélie Mauresmo in the semifinals). By reaching the final, Henin-Hardenne became the eighth woman (after Maureen Connolly, Margaret Court, Chris Evert, Martina Navratilova, Steffi Graf, Monica Seles and Martina Hingis) to reach all four major finals in a calendar year.
| Women's singles | |
|---|---|
| 2006 US Open | |
| Champion | Maria Sharapova |
| Runner-up | Justine Henin-Hardenne |
| Score | 6–4, 6–4 |
Kim Clijsters was the reigning champion, but did not participate due to injury.
This marked the final major appearance of two-time major champion Mary Pierce, who lost to Li Na in the third round.
This marked the first major since the 1999 Australian Open where Serena Williams was unseeded. Needing a wild card to participate due to her ranking of world No. 139, Williams defeated top-20 players Daniela Hantuchová and Ana Ivanovic en route to the fourth round, where she was beaten by Amélie Mauresmo in three sets.