2000 US Open – Men's singles

Marat Safin defeated Pete Sampras in the final, 6–4, 6–3, 6–3 to win the men's singles tennis title at the 2000 US Open. It was his first major title.

Men's singles
2000 US Open
Champion Marat Safin
Runner-up Pete Sampras
Score6–4, 6–3, 6–3
Draw128
Seeds16

Andre Agassi was the defending champion, but lost in the second round to Arnaud Clément.

The tournament marked the first major main draw appearance of future world No. 1 and 2003 US Open champion Andy Roddick, and the first US Open main draw appearance of future world No. 1 and five-time US Open champion Roger Federer.

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