1921 Wimbledon Championships – Women's singles

Elizabeth Ryan defeated Phyllis Satterthwaite 6–1, 6–0 in the All Comers' Final, but the reigning champion Suzanne Lenglen defeated Ryan 6–2, 6–0 in the Challenge Round to win the Ladies' Singles at the 1921 Wimbledon Championships.

This was the last year that the defending champion received an automatic bye into the final (formally known as the Challenge round). Beginning in 1922, the defending champion was required to play in the regular Wimbledon draw.