11β-Hydroxysteroid dehydrogenase type 1

HSD11B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4P38, 1XU9, 2BEL, 2ILT, 2IRW, 2RBE, 3BYZ, 3BZU, 3CH6, 3CZR, 3D3E, 3D4N, 3D5Q, 3EY4, 3FCO, 3FRJ, 3H6K, 3HFG, 3OQ1, 3PDJ, 3QQP, 3TFQ, 4BB5, 4BB6, 4C7J, 4C7K, 4HFR, 4HX5, 4IJU, 4IJV, 4IJW, 4K1L, 4YYZ, 1XU7
Identifiers
Aliases	HSD11B1, 11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1, hydroxysteroid (11-beta) dehydrogenase 1, hydroxysteroid 11-beta dehydrogenase 1
External IDs	OMIM: 600713 MGI: 103562 HomoloGene: 68471 GeneCards: HSD11B1
EC number	1.1.1.146
Gene location (Human)
Chr.	Chromosome 1 (human)
End	209,734,949 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	192,946,383 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; islet of Langerhans; ; urethra; ; right lung; ; stromal cell of endometrium; ; upper lobe of left lung; ; skin of abdomen; ; vulva; ; subcutaneous adipose tissue; ; left coronary artery;
	Top expressed in
	left lobe of liver; ; right lung lobe; ; left lung; ; belly cord; ; left lung lobe; ; white adipose tissue; ; gallbladder; ; submandibular gland; ; subcutaneous adipose tissue; ; kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	11-beta-hydroxysteroid dehydrogenase (NADP+) activity; oxidoreductase activity; 11-beta-hydroxysteroid dehydrogenase [NAD(P) activity]; steroid binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	glucocorticoid biosynthetic process; lung development; lipid metabolism; steroid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3290
	15483
	ENSG00000117594
	ENSMUSG00000016194
	P28845
	P50172
	NM_181755; NM_001206741; NM_005525
	NM_001044751; NM_008288
NP_001193670; NP_005516; NP_861420; NP_001193670.1; NP_005516.1;
	NP_861420.1
	NP_001038216; NP_032314
	Wikidata
View/Edit Human	View/Edit Mouse

11β-Hydroxysteroid dehydrogenase type 1, also known as cortisone reductase, is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It belongs to the family of short-chain dehydrogenases. It is encoded by the HSD11B1 gene.

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