1-Amino-5-phosphonoindan-1-carboxylic acid

1-Amino-5-phosphonoindan-1-carboxylic acid (APICA) is a drug that is used in neuroscience research. It is a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and has been useful in the study of this receptor subfamily.

This article is about the metabotropic glutamate receptor antagonist. For the cannabinoid drug, see APICA (synthetic cannabinoid drug).
APICA
Clinical data
ATC code
  • none
Identifiers
  • 1-Amino-5-phosphonoindan-1-carboxylic acid
ChemSpider
ChEMBL
Chemical and physical data
FormulaC10H12NO5P
Molar mass257.182 g·mol−1
3D model (JSmol)
SMILES
  • O=P(O)(O)c(c2)ccc1c2CCC1(N)C(O)=O
  • InChI=1S/C10H12NO5P/c11-10(9(12)13)4-3-6-5-7(17(14,15)16)1-2-8(6)10/h1-2,5H,3-4,11H2,(H,12,13)(H2,14,15,16) Y
  • Key:ZNQZXIHSJUDIKL-UHFFFAOYSA-N Y
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