Alpha-2C adrenergic receptor

ADRA2C
Identifiers
Aliases	ADRA2C, ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR, adrenoceptor alpha 2C
External IDs	MGI: 87936 HomoloGene: 20170 GeneCards: ADRA2C
Gene location (Human)
Chr.	Chromosome 4 (human)
End	3,768,526 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	35,439,107 bp
RNA expression pattern
	Top expressed in
	canal of the cervix; ; ascending aorta; ; popliteal artery; ; saphenous vein; ; vena cava; ; right coronary artery; ; stromal cell of endometrium; ; nipple; ; putamen; ; left coronary artery;
	Top expressed in
	nucleus accumbens; ; entorhinal cortex; ; superior frontal gyrus; ; Region I of hippocampus proper; ; retinal pigment epithelium; ; amygdala; ; olfactory tubercle; ; inferior colliculus; ; hippocampus proper; ; primary motor cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; epinephrine binding; protein homodimerization activity; signal transducer activity; adrenergic receptor activity; protein binding; alpha-2A adrenergic receptor binding; alpha2-adrenergic receptor activity; protein heterodimerization activity;
Cellular component	cytoplasm; axon terminus; integral component of membrane; endosome; membrane; plasma membrane; integral component of plasma membrane; axon; glutamatergic synapse; integral component of postsynaptic membrane; integral component of postsynaptic density membrane; neuronal cell body;
Biological process	G protein-coupled receptor signaling pathway; activation of protein kinase B activity; negative regulation of epinephrine secretion; regulation of sensory perception of pain; regulation of smooth muscle contraction; regulation of insulin secretion; female pregnancy; cell-cell signaling; negative regulation of norepinephrine secretion; negative regulation of uterine smooth muscle contraction; adenylate cyclase-activating adrenergic receptor signaling pathway; regulation of vasoconstriction; positive regulation of neuron differentiation; positive regulation of vasoconstriction; signal transduction; platelet activation; positive regulation of MAPK cascade; adrenergic receptor signaling pathway; receptor transactivation; adenylate cyclase-modulating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	152
	11553
	ENSG00000184160
	ENSMUSG00000045318
	P18825
	Q01337
	NM_000683
	NM_007418
	NP_000674
	NP_031444
	Wikidata
View/Edit Human	View/Edit Mouse

The alpha-2C adrenergic receptor (α_2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.

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